发给老马备查:
# R/ ?% _1 n$ p5 r: y5 d0 n滴水察海(69304838) 15:23:238 O: w+ `; O* D. j
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
" F/ p$ G& S, G8 ] Z吉非替尼和S-1连用的依据
% q, r/ H2 @0 ]* HGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
) g2 ]* Z' ?% q. R8 L) {6 {" i是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
^5 T1 G3 |4 [; i% J这样是不是推理出,耐药后,可以用S-1和培美了?
5 S- A, Z! e/ m$ Z结论:# a# `3 I9 _; {3 u' @# o
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |