脑部放疗，上午比下午敏感许多！
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Cancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9.& F% }- h' O' T6 H6 F1 Z" \: g
Gamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?
1 q. Y) T' Z* vRahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.4 F6 h5 Z4 V( R' D% m% f
SourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.
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" ?7 { f" X0 A$ o$ I" P8 ], AAbstract
" m. g/ D" W4 E0 w% h# fBACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time." _- [0 B6 b/ \! s0 b) ?7 |% \# W
$ L) }4 K3 r% C4 TMETHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic.4 T6 {9 q' ~ c! _
% t3 c0 }: V5 I( B7 yRESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).
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CONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.) j, A3 ^+ X8 j8 F% V) H, O5 z( h7 Y
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手术后一个月复查增强CT，纵隔七区淋
8月23日手术，9月23日做增强ct，看到纵膈七区又有肿大淋巴结，瞬间不淡定了：手术前派
老公刚刚54岁，确诊肺癌，手术中发现
各位朋友好。
度过了慌乱的一个月，有机会发现了这个论坛，如获至宝，说说我家
母亲肺腺癌，9年靶向耐药后，如何选
2017年5月，因持续干咳入院检查，肺部弥漫型结节，支气管镜确诊肺腺癌，四期。基因检
倍瑞博，为十余年抗癌路保驾护航
【病史简述】
2009年，老爸确诊肾透明细胞癌，肾透明属于相对温和的癌种，所以根治术
一线三代29个月，四次培美加卡铂出现
患者信息：女，57岁。确诊时肺内广泛转移+脑部多发转移+肝部转移+骨转移。组织检测600
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显身卡
